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Howard Hughes was an American business magnate, investor, aviator, aerospace engineer, film maker and philanthropist. Hughes is also remembered for his eccentric behavior and reclusive lifestyle in later life, caused in part by a worsening obsessive–compulsive disorder and chronic pain. When Dr. Rodney McKay saw Dr. Malcolm Tunney for the first time in years, Tunney said "You know, most people think you've lost your mind. That you've gone, uh, Howard Hughes." McKay responded by saying "Just because I don't call anymore doesn't mean I'm keeping my urine in jars." (SGA: "Brain Storm")

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